IMPACT OF METFORMIN AND HIS RELATIONSHIP WITH HBA1C, FBG AND VITAMIN B12 IN MALES AND FEMALES DURING THE DIFFERENT AGE GROUPS IN THE HUMAN BODY

Abstract

Metformin is an oral anti-diabetic drug that been used for decades However, long-term treatment with metformin has been shown to reduce vitamin B12 (vit B12) levels and causes unpleasant side effects. Studies on the influence of the duration and prevalence of vit B12 deficiency among type 2 diabetic people are lacking. The aim of this study is to investigate the impact of using metformin on the serum levels of vit B12 and glycated hemoglobin (HBA1C) among Libyan patients with type 2 diabetes,  and evaluate the relationship between vit B12 deficiency and metformin use. The result shown the highest rate was in the age group from 31 - 40 and the lowest rate was In the age group ≤ 20, The arithmetic mean values ​​of HBA1C, FBG are high in the patient group and the values ​​of Vitamin B12 are low compared to people with low HBA1C, FBG and normal Vitamin B12 level (control group), This indicates that there is an inverse relationship between high HbA1c levels and Vitamin B12 levels in diabetic patients who use metformin treatment.  however, there was no significant difference between the mean of HBA1C values ​​in the patient group compared to the control group at Statistical level (P<0.05). Our recommend are conduct a more in-depth study of metformin and levels of both cumulative blood glucose and vitamin B12 in the body, and the relationship of metformin to pancreatic hormones such as glucagon, insulin, and blood glucose levels. And to expanding the study of this aspect and obtaining more samples in a longer period of time. In conclusion the results of this study showed that the highest rate was in the age group from 30 - 40 and the lowest rate was In the age group from ≤ 20, the HBA1C rate in the patient group was higher than the control group, However, there was no significant difference between the mean of HBA1C values ​​in the patient group compared to the control group at Statistical level (P<0.05).